Computer Science Research
Jamie is currently employed as a Scientific Programmer (Research Software Engineer) at the
Insitute of Cancer Research, London.
Jamie undertook and completed his Doctorate at Royal Holloway University of London where he conducted research in the Center for Systems and Synthetic Biology and department of Computer Science.
[ visit academic site ]
A list of Jamie's research publications can be found under the
papers section.
Drug
Design, Chemical, Pharmacological research
After completing his masters, Jamie assisted research efforts at the Biomedical Sciences department of
St. Georges Hospital Medical
School working with Prof. Brian Austen (chair of the Alzheimers association)
on developing neuroprotective drug molecules for neurodegenerative disorders.
The current drugs under development are Peptide based PDZ binding ligands
Jamie-3-Asn and Jamie-3-Glu based on the work of Pizerchio and Spaller et al and
Austen et al.
The
current drugs under development are Peptide based PDZ binding ligands
Jamie-3-Asn and Jamie-3-Glu based on the work of Pizerchio and Spaller et al and
Austen et al.
Continuation
of this work involves using Immunohistochemistry to label and visualise the
peptide drugs within the cells (The
gallery hosts some images from this process). Various cellular components
and a location on the Jamie-3 drug molecule are labelled with antibodies and
fluorescent dyes which fluoresce (glow) on application of laser light at a
particular wavelength. This allows us to visualise the penetration and the co-localisation
of the drug with the other stained cellular components.
This work has been presented as a Poster Presentation at RSC (The Royal Society
of Chemistry)
Protein
and Peptide Science Group Early Stage Researcher Meeting in November 2011
and subsequently at St.
Georges Research Day November 2011
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